The antibacterial bactericidal acid-agent wide spectrum of groups semisynthetic penicillins. Inhibits transpeptidase, violates the synthesis of peptidoglycan (the reference protein of the cell wall) during the division and growth, causes lysis omnadren 250 jelfa of the bacteria. It is active against aerobic Gram-positive bacteria: Staphylococcus spp. (except for strains producing penicillinase), Streptococcus spp, Listeria monocytogenes, Enterococcus faecalis and gram-negative aerobic bacteria:. Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Escherichia coli, Shigella spp, Salmonella spp, Helicobacter pylori.. Microorganisms that produce P-lactamase are resistant to the action of amoxicillin.
Absorption – a fast, high (93%), food intake has no effect on the absorption is not destroyed in the acid environment of the stomach. When administered in a dose of 250 mg and 500 mg, the maximum concentration of – 5 mg / ml and 10 ug / ml, respectively. The time to maximum concentration after oral administration -. 1-2 hours has a large volume of distribution – higher concentrations are found in the plasma, bronchial secretions (bronchial secretions in purulent allocation weak), liver, lymph nodes, uterus, ovaries, paranasal sinuses, pleural and peritoneal fluid, saliva and tear fluid, urine contents skin blisters, lung tissue, intestinal mucosa, liquid omnadren 250 jelfa middle ear and paranasal sinuses, bone, adipose tissue, the gall bladder (the concentration in the bile exceeding the plasma concentration is 10 times – during normal patency bile ducts), fetal tissues. With increasing doses of 2-fold concentration is also increased by 2 times.
- infections of the upper respiratory tract (tonzillofaringit, sinusitis, acute otitis media);
- infections of the lower respiratory tract (acute bacterial bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia);
- infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, endometritis, cervicitis, gonorrhea);
- abdominal infections (peritonitis, cholangitis, cholecystitis);
- Helicobacter pylori eradication in patients with duodenal ulcer or gastric (always in combination with other drugs);
- infections of skin and soft tissues (erysipelas, impetigo, secondarily – infected dermatitis);
- leptospirosis, listeriosis;
- Lyme disease;
- infections of the gastrointestinal tract (enterocolitis, typhoid fever, dysentery, salmonellosis (caused by Salmonella typhi, sensitive to ampicillin), salmonellonositelstvo;
- prophylaxis of bacterial endocarditis in surgical procedures in the mouth and upper airways.Contraindications
- Hypersensitivity (including to other penicillins, cephalosporins, carbapenems.);
- infectious mononucleosis, lymphatic leukemia;
- congenital fructose intolerance, glucose malabsorption syndrome / galactose enzyme deficiency or sucrase-isomaltase.Precautions : allergic reactions (including history – asthma, hay fever), gastrointestinal disease in history (especially colitis, associated with the use of antibiotics), kidney failure, pregnancy and lactation.Pregnancy and lactation :
The drug can be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
Amoxicillin is excreted in small amounts in breast milk, therefore, if necessary, possible to use during lactation.
Side effect From the digestive system: nausea, vomiting, diarrhea; rarely – stomatitis, esophagitis, glossitis, a moderate increase in activity of “liver” transaminases, goiter, change in taste, pseudomembranous omnadren 250 jelfa enterocolitis, jaundice (benzoate increase the risk of the newborn). On the part of the central and peripheral nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavioral changes, depression, peripheral neuropathy, headache, dizziness; rarely -gallyutsinatsii and cramps. Allergic reactions: urticaria, erythematous maculopapular rash, itchy skin, bronchospasm, angioedema, rhinitis, conjunctivitis; -lihoradka rarely, skin flushing, erythema, joint pain, exfoliative dermatitis, erythema poliformnaya (including Stevens – Johnson); reactions similar to serum sickness; in rare cases – anaphylactic shock. Laboratory findings: neutropenia, thrombocytopenic purpura, anemia, eosinophilia, leukopenia. Other: tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or low resistance of the body).
Overdsing Symptoms: nausea, vomiting, diarrhea, crystalluria, disruption of water and electrolyte balance (as a result of vomiting and diarrhea), seizures, agitation, confusion. Treatment: symptomatic – gastric lavage, activated charcoal, saline laxatives, medicines for the maintenance of water and electrolyte balance, hemodialysis.
Interaction with other medicinal products
Antacids, glucosamine, laxatives, drugs, food, aminoglycosides – slow down and reduce absorption; . ascorbic acid increases the absorption of
bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampin, quinolones) have a synergistic effect; . bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) – antagonistic (reduced efficacy of amoxicillin)
Increases the effectiveness of indirect omnadren 250 jelfa anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces efficiency estrogensoderjath peroralnyh contraceptive drugs during metabolism that produce para-aminobenzoic acid, ethinyl estradiol – the risk of bleeding “breakthrough”.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs and drugs that block tubular secretion – decrease tubular secretion, increase the concentration of . amoxicillin blood
simultaneous appointment with allopurinol: increased risk of skin rash.
reduces clearance and increases the toxicity of methotrexate.
enhances the absorption of digoxin.
During treatment with amoxicillin can: false positive Coombs test sample and the presence of glucose in urine.
In exchange treatment is necessary to monitor the state functions of blood, liver and kidneys.
Prolonged use may develop cases of superinfection, candidiasis (particularly vulvovaginal candidiasis).
In case of severe, persistent diarrhea which may indicate pseudomembranous colitis should stop reception drug and consult a physician.
in the treatment of patients with bacteremia may develop reactions bacteriolysis (Jarisch-Herxheimer).
in patients with hypersensitivity to penicillin, may be cross-allergic reactions to cephalosporin antibiotics.
in the treatment of mild diarrhea on the background of a course of treatment should be avoided antidiarrheal drugs that reduce intestinal motility; You can use kaolin or omnadren 250 jelfa attapulgitsoderzhaschie antidiarrheals.In severe diarrhea should consult a doctor.
Treatment continues for sure 48-72 hours after the disappearance of clinical signs of the disease.
In an application estrogensoderjath oral contraceptives and amoxicillin should be possible to use other or additional contraceptive methods.
It is necessary to adjust the dosing regimen (see. “Section dosage and administration).
In 5 ml suspension for oral administration contains 2.7 g of sucrose, so Hikontsil, powder for suspension for oral administration is not recommended for patients with congenital fructose intolerance, glucose malabsorption syndrome / galactose or a deficiency of the enzyme sucrase-isomaltase .
Effects on ability to drive a car or other mechanical means : there is no data on the effect of amoxicillin on the ability to drive a car or other mechanical means.
Release form for suspension Powder for oral administration, 250 mg / 5 ml. 64.8 g of powder is placed in a vial of brown (type III) graduated at 100 ml. with plastic cover «cap – to – cap». , white, 1 bottle complete with a dosing spoon made of polyethylene is placed in a cardboard pack together with instructions for use.
powder for suspension for oral administration:. In a dark place at a temperature no higher than 25 ° C
. Keep out of reach of children preparing a slurry suitable for 7 days at a temperature no higher than 25 ° C or 14 days in a refrigerator .
Do not use after the expiration date.